Pharmaceutically useful nitrogen containing heterocyclic derivat

Details Pharmaceutically useful nitrogen containing heterocyclic derivat Pharmaceutically useful nitrogen containing heterocyclic derivat

1975-11-03

1977-08-09

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

A61K 31445

Patent

active

040411656

ABSTRACT:
Bis-basic substituted aromatic polycyclic compounds of the following structure are useful in treating conditions of delayed hypersensitivity: ##STR1## wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, dibenzofuran, dibenzothiophene, carbazole, N-(lower)alkyl carbazole, xanthene, xanthone, thioxanthene, phenoxathiin, or anthraquinone; Y represents carbonyloxy, carbonylthio, oxygen, divalent sulfur or carbonyl with the provisos that when Y is carbonyloxy or carbonylthio, [W] is other than thioxanthene, phenoxathiin or anthraquinone, when Y is oxygen or divalent sulfur, [W] is other than thioxanthene or phenoxathiin, and when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms with the proviso that when Y is carbonyloxy or carbonylthio, A contains at least 2 straight chain carbon atoms, that is, an ethylene radical; R represents hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, phenyl or benzyl; and pharmaceutically useful acid addition salts.

REFERENCES:
patent: 3531489 (1970-09-01), Albrecht et al.
patent: 3592819 (1971-07-01), Fleming et al.
patent: 3662062 (1972-05-01), Krueger et al.
patent: 3673191 (1972-06-01), Albrecht et al.
patent: 3692907 (1972-09-01), Fleming et al.
patent: 3707471 (1972-12-01), Albrecht et al.

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