Pharmaceutically efficacious pteridine derivatives

Details Pharmaceutically efficacious pteridine derivatives Pharmaceutically efficacious pteridine derivatives

1990-04-20

1992-06-23

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514249, 544118, 544249, 558408, 558401, 558388, 546230, A61K 31495, C07D47508

Patent

active

051243261

ABSTRACT:
A pharmaceutically efficacious pteridine compound of formula I: ##STR1## wherein A denote a bridging hydrocarbon group containing 1 to 8 carbon atoms and containing a ##STR2## group directly bonded to the phenyl group and one of the methylene radicals of the bridging A group is optionally replaced by --O--; R.sub.1 is hydrogen, a cycloalkyl group with up to 7 carbon ring atoms, or an alkyl group having 1 to 6 carbon atoms, benzyl, or aryl; R.sub.2 is hydrogen or an alkyl group having 1 to 6 carbon atoms, or wherein R.sub.1 and R.sub.2 together form a five- or six-membered heterocyclic group which optionally contains additional hetero atoms selected from the group consisting of nitrogen, oxygen, and sulfur; R.sub.3 is hydrogen or an alkyl group having 1 to 3 carbon atoms; R.sub.3 ' is hydrogen, an optionally substituted alkyl group having 1 to 3 carbon atoms, carboxyl, hydroxyl or R.sub.3 and R.sub.3 ' together with the carbon atom to which they are attached form a cycloalkyl group and the pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
patent: 3081230 (1963-03-01), Weinstock et al.
patent: 4252809 (1981-02-01), Knauf et al.
patent: 4621085 (1986-11-01), Borchard
patent: 4874763 (1989-10-01), Hofmann et al.
patent: 4910203 (1990-03-01), Rietzel et al.
Endo, "Topics in Current Chemistry" vol. 128, pp. 100-103 (1985).

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