Pharmaceutically active uridine esters

Details Pharmaceutically active uridine esters Pharmaceutically active uridine esters

2011-03-29

2011-03-29

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S049000, C536S028530, C554S001000

Reexamination Certificate

active

07915234

ABSTRACT:
The present invention relates to novel uridine esters of the general formulawhereinR represents a carboxylic acid residue, preferably a fatty acid residue and R′ represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination.

REFERENCES:
patent: 5583117 (1996-12-01), von Borstel et al.
patent: 5736531 (1998-04-01), von Borstel et al.
Haung et al. (Synthetic Communications (1997), 27 (4), pp. 681-690) (Abstract Sent).
Huang et al. (Languir (2000), 16 (8), 3937-3940)(Abstract sent).
J. Huang et al, Synthetic Communications, vol. 27, 1997, pp. 681-690.
F. Moris et al, J. Org. Chem, vol. 58, 1993, pp. 653-660.
Piera T. Calissi et al.; The Annals of Pharmacotherapy; vol. 29, Jul./Aug. 1995, pp. 769-777.

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