Pharmaceutically active isoindoline derivatives

Details Pharmaceutically active isoindoline derivatives Pharmaceutically active isoindoline derivatives

2006-02-28

2006-02-28

Desai, Rita (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S201000

Reexamination Certificate

active

07005438

ABSTRACT:
Isoindolin-1-one and Isoindoline-1,3-dione substituted in the 2-position with a 2,6-dioxo-3-hydroxypiperidin-5-yl group, which may be further substituted in the 5-position with alkyl or halogeno, and in the 4-position with alkyl or a nitrogen-containing group are inhibitors of, and thus useful in the treatment of disease states mediated by, TNFα. A typical embodiment is 2-(2,6-dioxo-3-hydroxy-5-fluoropiperidin-5-yl)-4-aminoisoindolin-1-one.

REFERENCES:
patent: 6458810 (2002-10-01), Muller et al.

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