Pharmaceutically active cyclohexyl compounds and their preparati

Details Pharmaceutically active cyclohexyl compounds and their preparati Pharmaceutically active cyclohexyl compounds and their preparati

1979-04-18

1981-08-11

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260464, 260544L, 560126, 560128, 562400, 562473, 562491, 562492, 562508, 562510, 564123, 564161, 564169, 564170, 564171, 564181, 564191, 424320, 424324, A61K 3119, C07C 6220, C07C 6210, C07C 6108

Patent

active

042834201

ABSTRACT:
The chemical compounds of the invention are useful as the active compound in drugs because of their anticonvulsant and/or antianoxic activity. They have the general formula ##STR1## wherein Z is a hydroxyl group; a group--OM wherein M is an alkali metal atom or an equivalent atom fraction of an alkaline-earth metal or an amino group such as --NH.sub.2, and R is a linear or branched alkyl group containing from 1 to 9 carbon atoms, and optionally substituted by one or more halogen atoms; a linear or branched alkenyl or alkynyl, alkoxyalkyl, or acylalkyl group containing from 2 to 9 carbon atoms and optionally substituted by one or more halogen atoms; an aryl or arylalkyl or aryloxyalkyl group comprising at least one aromatic radical and an alkyl chain having from 1 to 4 carbon atoms.

REFERENCES:
patent: 2404588 (1946-07-01), Martin
patent: 3392198 (1968-07-01), Paulshock
Tilford, J. Am. Chem. Soc., 71 p. 1705-1709 (1949).
Meerwein, Annalen, 419 p. 159-175.
Reichstein, Helv. Chem., 18 p. 721-724 (1935).
Shive, J. Am. Chem. Soc. 63 p. 2979-2984 (1941).
Tarbouriech, Compt. Rewd. 150 p. 1606-1607.

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