Pharmaceutically active compositions containing adriamycin and d

Details Pharmaceutically active compositions containing adriamycin and d Pharmaceutically active compositions containing adriamycin and d

1978-07-24

1981-04-21

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Lymphokine

424180, 536 17A, A61K 31705, C07H 1524

Patent

active

042632790

ABSTRACT:
Novel pharmaceutically active compositions of matter comprise in combination a low-molecular-weight anti-cancer drug chemically linked to antibodies selective or specific to tumor antigens. The preferred linkage is via covalent bonds, whether directly or via a linking agent. A method of treatment of mammals afflicted with malignant growth comprises administering a pharmaceutical composition of matter defined above.

REFERENCES:
patent: 3100203 (1963-08-01), Borchert
patent: 3794635 (1974-02-01), Evans
patent: 3803124 (1974-04-01), Arcamone et al.
patent: 3957755 (1976-05-01), Jolles
patent: 4093607 (1978-06-01), Sela et al.
O'Bryan et al., "Cancer," vol. 32, No. 1, pp. 1-8, Jul. 1973.
Frei, "Cancer," vol. 30, No. 6, pp. 1656-1661, Dec. 1972.
Johnson et al., "Cancer Treatment Reviews," pp. 1-31, 1975.
Levy et al., "Cancer Research," vol. 35, pp. 1182-1185, 1975.
Hurwitz et al., "Cancer Res.," vol. 35, pp. 1175-1181, 1975.
Hurwitz et al., "Cancer, Europ. J.," vol. 14, pp. 1213-1220, 1978.

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