Pharmaceutically active composition extracted from tanacetum par

Details Pharmaceutically active composition extracted from tanacetum par Pharmaceutically active composition extracted from tanacetum par

1993-01-29

1995-11-14

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514468, 424450, A61K 3578

Patent

active

054664519

ABSTRACT:
Extraction of pharmaceutically active compositions from a mixture of numerous ingredients, in particular from comminuted plants, such as Tanacetum parthenium, succeeds with a high yield and a surprisingly improved stability of the active substances when the extraction is carried out with a gas, preferably CO.sub.2, in the supercritical state.

REFERENCES:
patent: 4758433 (1988-07-01), Johnson et al.
patent: 4847422 (1989-07-01), Klemola et al.
patent: 4996317 (1991-02-01), O'Brien et al.
patent: 5073267 (1991-12-01), Adda et al.
patent: 5196575 (1993-03-01), Sebastian
Makheja et al., "The Active Principle in Feverfew" Lancet, Nov. 7, 1981, p. 1054.
Rodriguez, "Ecogeographic Distribution of Secondary Constituents" in Parthenium, Biochemical Systematics and Ecology, vol. 5, pp. 207-218 (1977).
Brunner et al., "Zum Stand der Extraktion mit komprimierten Gasen", (on the state of extraction with compressed gases), Chem.-Ing.-Tech. vol. 53, No. 7, pp. 529-542 (1981).
List et al., Technologie pflanzlicher Arzneizubereitungen pp. 159-173, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart (1984).
R. M. Smith, et al., "Supercritical fluid extraction and gas chromatographic . . . feverfew . . . " J. Chrom. 627:225-261 1992.

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