Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing
Patent
1995-02-02
1997-05-20
Kishore, Gollamudi S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Silicon containing
556405, 562455, 562567, 564 84, 564 88, 564 95, 564169, 564199, 564200, C07F 902, C07C22900, C07C30300
Patent
active
056313942
ABSTRACT:
This invention provides a compound having the formula R.sup.1 --Y.sup.1 --CHZ.sup.1 --CH(NY.sup.2 Y.sup.3)--CH.sub.2 --Z.sup.2, wherein: R.sup.1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y.sup.1 is --CH.dbd.CH--, --C.tbd.C-- or --CH(OH)CH(OH)--; Z.sup.1 is OH or a conversion-inhibiting group; Z.sup.2 is a conversion-inhibiting group; Y.sup.2 is H, a phenyl group, an alkyl-substituted phenyl group having from 1 to about 6 carbons in the alkyl chain, or an alkyl chain having from 1 to 6 carbons; Y.sup.3 is H or a group having the formula --C(O)R.sup.2 or --S(O).sub.2 R.sup.2 ; R.sup.2 is a straight-chained alkyl, alkenyl or alkynyl group having from 1 to 23 carbon atoms in the chain; and when Z.sup.2 is an amino, R.sup.2 is an aliphatic chain having from 1 to 9 or from 19 to 23 carbon atoms in the aliphatic chain.
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Ahmad Imran
Janoff Andrew S.
Mayhew Eric
Wei Yong
Kishore Gollamudi S.
Rubin Kenneth B.
The Liposome Company Inc.
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