Pharmaceutically active aza-bicyclo-benzamide derivatives

Details Pharmaceutically active aza-bicyclo-benzamide derivatives Pharmaceutically active aza-bicyclo-benzamide derivatives

1979-12-26

1981-06-16

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546112, 546124, 260239BF, 2602444, 2602457, 26032625, 424244, 424267, 424274, C07D45104, C07D45114, A61K 3146, A61K 31455

Patent

active

042737788

ABSTRACT:
This invention relates to novel substituted benzamides having useful pharmacological properties, to pharmaceutical compositions containing them, and to a process for their preparation.
N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide, 1-ethyl-2(2-methoxy-5-sulphamoylbenzamidomethyl)pyrrolidine and N-[4'-(1"-benzyl)-piperidyl]-2-methoxy-4-amino-5-chlorobenzamide are well known compounds having useful pharmacological activity such as the ability to regulate the gastro-intestinal function anti-emetic activity and CNS activity.
It has now been found that a certain structurally distinct class of substituted benzamides also has useful pharmacological activity, in particular dopamine antagonist activity.

REFERENCES:
patent: 4213983 (1980-07-01), Hadley
Minae et al., Chemical Abstracts, vol. 86, (25), 189,555z, Jun. 20, 1977.

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