Pharmaceutically active agents that impede amyloid formation in

Details Pharmaceutically active agents that impede amyloid formation in Pharmaceutically active agents that impede amyloid formation in

1994-06-27

1996-10-22

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514460, 514724, 514407, 514274, 514378, 514379, 514261, 514903, 514883, A61K 31515, A61K 3144, A61K 3135, A61K 3134

Patent

active

055677207

ABSTRACT:
Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation of amyloid fibrils associated with Alzheimer's disease and other forms of cerebral amyloidosis. Compounds that, at in-tissue concentrations of 10.sup.-5 M or less, inhibit amyloid formation in a test animal injected intracerebrally with dense microspheres are particularly useful in inhibiting treating cerebral amyloidosis.

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