Pharmaceutically active 3-aryl-2-fluoro-1-olefins

Details Pharmaceutically active 3-aryl-2-fluoro-1-olefins Pharmaceutically active 3-aryl-2-fluoro-1-olefins

1990-06-15

1991-11-26

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

549 82, 568655, 568766, C07C 3910, C07C 3924

Patent

active

050684655

ABSTRACT:
This invention relates to novel 3-aryl-2-fluoro-1-olefins and their pharmacological use as dopamine beta-hydroxylase DBH inhibitors in the treatment of DBH mediated conditions such as hypertension.

REFERENCES:
patent: 3850997 (1974-11-01), Brossi et al.
patent: 4116975 (1990-07-01), Klaus et al.
patent: 4981868 (1991-01-01), McCarthy et al.
J. McCarthy et al., Tetrahedron Letters, 31, No. 7, pp. 973-976, 1990.
The publication by Bey et al., J. Med. Chem., 27, 9 (1984).
M. Kolb et al., J. Med. Chem. 30, 267 (1987).
B. Rajashekhar et al., J. Biol. Chem., 259, No. 11, 6925 (1984).

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