Pharmaceutically active 1,2,3,4,4a,5,10,10a-octahydro-benzo[g]qu

Details Pharmaceutically active 1,2,3,4,4a,5,10,10a-octahydro-benzo[g]qu Pharmaceutically active 1,2,3,4,4a,5,10,10a-octahydro-benzo[g]qu

1982-10-14

1986-01-21

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514239, 546101, 544126, 560 35, 560 45, 560 10, 560 53, C07D22108, C07D40112, C07D40106, A61K 31435

Patent

active

045658188

ABSTRACT:
A 6- and/or 7-oxy-trans-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline in which the 3-position is substituted by an optionally amidated carboxy group, an optionally etherified hydroxymethyl group, a cyanomethyl group, an alkyl- or aryl-thiomethyl group or a sulfamoylamino or carbamoylamino group, or a physiologically-hydrolysable and -acceptable ester thereof. The subject compounds are useful as pharmaceuticals, in particular as prolactin secretion inhibitors, dopaminergic agents ad dopamine receptor stimulating agents.

REFERENCES:
patent: 3839338 (1974-10-01), Albertson et al.
patent: 4100164 (1978-07-01), Michne
patent: 4235909 (1980-11-01), Bach et al.
Bach et al., II, J. Med. Chem. 23, 481-91 (1980).
Cannon et al., J. Med. Chem. 23 (1), 1-5 (1980).
Cannon et al., Med. Chem. Advances, 369-381, Pergamon Press, 1981.
Cannon et al., J. Heterocyclic Chem. 17, 1633-1636 (1980).
Walsh, et al., J. Org. Chem. 39 (25), 3705-3708 (1974).

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