Pharmaceutically acceptable inorganic and organic salts of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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Reexamination Certificate

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07153965

ABSTRACT:
Methods for the preparation of pharmaceutically acceptable organic or inorganic salts of 5-methylpyrazinecarboxylic acid-4-oxide esters including tris(hydroxymethyl)aminomethanol, N,N-dimethylethanolamine, N-methyl-D-glucamine, L-Lysine, L-arginine, Na, K, Ca and Mg. The esters of 5-methylpyrazinecarboxylic acid-4-oxide are oxidized in aqueous hydrogen peroxide at a pH of 2.5 to 7 in the presence of a catalyst selected from the group consisting of sodium tungstate, tungstic acid and ammonium heptamolybdate. The salts are formed by saponification of the esters followed by alcohol precipitation, or by reaction with a metal trimethylsilanoate, or by the reaction of organic bases with the saponified acids.

REFERENCES:
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patent: 4866178 (1989-09-01), Venturello et al.
patent: 0201934 (1986-11-01), None
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patent: 1224365 (1989-09-01), None
McKay et al, “Oxidation Methods for Aromatic Diazines: Substituted Pyrazine N-Oxides, Pyrazine N,N′-Dioxides, and 2,2′:6:,2″-Terpyridine-1,1″-Dioxide” Heterocyclic Communications, vol. 7(4), pp. 307-312 (2001).

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