Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2006-12-26
2006-12-26
Tucker, Zachary C. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
active
07153965
ABSTRACT:
Methods for the preparation of pharmaceutically acceptable organic or inorganic salts of 5-methylpyrazinecarboxylic acid-4-oxide esters including tris(hydroxymethyl)aminomethanol, N,N-dimethylethanolamine, N-methyl-D-glucamine, L-Lysine, L-arginine, Na, K, Ca and Mg. The esters of 5-methylpyrazinecarboxylic acid-4-oxide are oxidized in aqueous hydrogen peroxide at a pH of 2.5 to 7 in the presence of a catalyst selected from the group consisting of sodium tungstate, tungstic acid and ammonium heptamolybdate. The salts are formed by saponification of the esters followed by alcohol precipitation, or by reaction with a metal trimethylsilanoate, or by the reaction of organic bases with the saponified acids.
REFERENCES:
patent: 4002750 (1977-01-01), Ambrogi et al.
patent: 4051245 (1977-09-01), Ambrogi et al.
patent: 4866178 (1989-09-01), Venturello et al.
patent: 0201934 (1986-11-01), None
patent: 62-263164 (1987-11-01), None
patent: 1224365 (1989-09-01), None
McKay et al, “Oxidation Methods for Aromatic Diazines: Substituted Pyrazine N-Oxides, Pyrazine N,N′-Dioxides, and 2,2′:6:,2″-Terpyridine-1,1″-Dioxide” Heterocyclic Communications, vol. 7(4), pp. 307-312 (2001).
Caudill Jonathan
Cooney Mark
Nigam Satish C.
Balogh Imre
Davis William J.
ISP Investments Inc.
Tucker Zachary C.
LandOfFree
Pharmaceutically acceptable inorganic and organic salts of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutically acceptable inorganic and organic salts of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutically acceptable inorganic and organic salts of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3667617