Pharmaceutically acceptable fixed-dried human blood platelets

Details Pharmaceutically acceptable fixed-dried human blood platelets Pharmaceutically acceptable fixed-dried human blood platelets

1996-12-31

1999-11-30

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

424532, 435 2, 4352402, 43524031, 435260, 436501, A61K 3518

Patent

active

059938048

ABSTRACT:
Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.

REFERENCES:
patent: 4145185 (1979-03-01), Brinkhous et al.
patent: 4157383 (1979-06-01), Sedlacek et al.
patent: 4199954 (1980-04-01), McGill
patent: 4287087 (1981-09-01), Brinkhous et al.
patent: 4302355 (1981-11-01), Turner, Jr. et al.
patent: 4510126 (1985-04-01), Fuhge et al.
patent: 4605413 (1986-08-01), Urry et al.
patent: 4695460 (1987-09-01), Holme
patent: 4717654 (1988-01-01), Savoca et al.
patent: 4764463 (1988-08-01), Mason et al.
patent: 4880788 (1989-11-01), Moake et al.
patent: 4994367 (1991-02-01), Bode et al.
patent: 5030560 (1991-07-01), Sinor et al.
patent: 5043261 (1991-08-01), Goodrich et al.
patent: 5059518 (1991-10-01), Kortright et al.
patent: 5151360 (1992-09-01), Handa et al.
patent: 5162430 (1992-11-01), Rhee et al.
patent: 5165938 (1992-11-01), Knighton
patent: 5213814 (1993-05-01), Goodrich, Jr. et al.
patent: 5236716 (1993-08-01), Carmen et al.
patent: 5248506 (1993-09-01), Holme et al.
patent: 5344752 (1994-09-01), Murphy
patent: 5358844 (1994-10-01), Stessel et al.
patent: 5376524 (1994-12-01), Murphy et al.
patent: 5378601 (1995-01-01), Gepner-Puszkin
patent: 5651966 (1997-07-01), Read et al.
Keyharin, J. Cell Sci., vol. 46, pp. 289-297, 1980.
Brinkhous et al., Thromb. Res., vol. 13, pp. 591-597, 1978.
J. P. Allain et al., Platelets Fixed with Paraformaldehyde: A New Reagent for Assay of Von Willenbrand Factor and Platelet Aggregating Factor, The Journal of Laboratory and Clinical Medicine, 85(2), pp. 318-328, Feb. 1975.
M. Terasaki et al., Localization of Endoplasmic Reticulum in Living and Glutaraldehyde-Fixed Cells with Fluorescent Dyes, Cell, 38, pp. 101-108, 1984.
East Carolina University, Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques, First Year Quarterly Report, 1989.
M. S. Read et al., Rehydrated Platelets Maintain Hemostatic Properties, The FASEB Journal Abstracts Part II, vol. 4(1), issued Feb. 29, 1990.
Office of Naval Research, Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques, First Annual Report, 1990.
East CaroLina University, Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques, Quarterly Report (Second Quarter, 2nd Year), 1990.
ISTB & AABB 1990 Joint Congress, Stabilization of Platelet Membranes for Lyophilization and Dried Storage, Book of Abstracts, S551, 1990.
A. P. Bode et al., Stabilization of Platelet Membranes for Lyophilization and Dried Storage, American Association of Blood Banks Congress, 1990.
East Carolina University, Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques, Quarterly Report (Third Quarter, 2nd Year), 1990.
Office of Naval Research, Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques, Second Annual Report, issued Mar. 25, 1991, pp. 1-22.
M.S. Read et al., Studies with Dried and Rehydrated Platelets for Transfusion Products, The FASEB Journal I, vol. 5(1), issued Mar. 11, 1991.
L. M. Graham et al., Growth Factor Production Following Prosthetic Graft Implantation, Journal of Vascular Surgery, 13(5), pp. 742-744, May 1991.
S. L. Goodman et al., The Effects of Substrate-Absorbed Albumin on Platelet Spreading, J. Biomater, Sci. Polymer Edn., vol. 2, pp. 147-159, 1991.
A. P. Bode, Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques, Quarterly Report (First Quarter, 3rd Year), 1991.
A. P. Bode, Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques, Quarterly Report (Second and Third Quarter, 3rd Year), 1991.
Office of Naval Research, Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques, Third Annual Report, issued Apr. 21, 1992, pp. 1-11.
A. P. Bode, Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques, Quarterly Report (Fourth Quarter, 3rd Year), 1992.
R. P. Goodrich et al., Preservation of metabolic activity in lyophilized human erythrocytes, Proc. Natl. Acad. Sci., vol. 89, pp. 967-971, 1992.

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