Pharmaceutically acceptable agents for solubilizing, wetting, em

Details Pharmaceutically acceptable agents for solubilizing, wetting, em Pharmaceutically acceptable agents for solubilizing, wetting, em

1994-04-11

1996-04-16

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 46, 514937, A61K 912

Patent

active

055080235

ABSTRACT:
1,1,1,2,3,3,3-heptafluoropropane (HFC-227) has been identified as a highly polar propellant. Surfactants which have an elevated value (9.6 or greater) for their hydrophilic-lipophilic balance (HLB) can be used as suspending, wetting, and lubricating agents or cosolvents in metered dose inhaler (MDI) formulations pressurized with HFC-227 or propellant blends that contain HFC-227. Particularly preferred surfactants include polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan mono-oleate, polyethylene glycol 300, propoxylated polyethylene glycol, polyoxyethylene 4 lauryl ether, and diethylene glycol monoethyl ether.

REFERENCES:
patent: 5118494 (1992-06-01), Schultz et al.
patent: 5225183 (1993-07-01), Purewal et al.
Moren, F. et al. (1993). Aerosols in Medicine. Principles, Diagnosis and Therapy. Elsevier Sci. Pub., pp. 303-319.
Martin et al., Physical Pharmacy, 3rd Ed., Lea & Febiger, Philadelphia, PA, 1983, pp. 452-455.
Martin et al., Physical Pharmacy, 3rd Ed., Lea & Febiger, Philadelphia, PA, 1983, pp. 544-573.
Whitham et al., "Alternative Propellants: Proprietary Rights, Toxicological Issues and Projected Licensing Problems"; Respiratory Drug Delivery IV, 1994, pp. 203-209.
Dalby et al., "CFC Propellant Substitution: P-134a as a Potential Replacement for P-12 in MDIs"; Pharmaceutical Technology, Mar. 1990, pp. 32-39.

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