Pharmaceutical use of pyridoxal derivative

Details Pharmaceutical use of pyridoxal derivative Pharmaceutical use of pyridoxal derivative

1994-04-04

1995-08-15

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514912, A61K 3144

Patent

active

054419727

ABSTRACT:
A novel use of the compound of the formula ##STR1## wherein R.sub.1 is hydrogen atom or lower alkyl and R.sub.2 is hydrogen atom or phosphoric acid group, or a pharmacologically acceptable salt thereof for preventing and treating cataract. The compounds of the formula (I) and pharmacologically acceptable salts thereof of the present invention inhibit initial changes in the lens, such as vacuolation and trochoidal change, and almost completely inhibit a decrease in the amounts of reduced glutathione and cysteine in the lens, so that they are advantageously used for the prevention of the onset and progress of cataract.

REFERENCES:
J. Am. Chem. Soc., vol. 70, 1948, pp. 3429-3431.
Org. Magn. Reson., vol. 20, No. 3, 1982, pp. 138-140.
Chemical Abstracts, 114:164089 (1991). Faggiani et al.

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