Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2008-04-29
2008-04-29
Flood, Michele (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C424S769000, C514S838000, C514S893000, C514S894000
Reexamination Certificate
active
10931791
ABSTRACT:
The present invention relates to compositions comprisingGraptopetalumand uses thereofGraptopetalumcan protect animals from liver diseases and medical conditions, such as inflammation, steatosis, and fibrosis. In particular,Graptopetaluminhibits proliferation of activated hepatic stellate cells, which play a pivotal role in liver fibrosis.Graptopetalumalso has anti-fibrosis activities as well as inhibits proliferation of lung fibroblasts. Therefore, in addition to being a prophylactic and therapeutic agent for the liver,Graptopetalumis useful against fibrosis or inflammation of tissues or organs other than the liver, in particular lung, kidney, and bladder. Other plants in the family of Crassulaceae, particularlyEcheveria,have similar effects asGraptopetalum.
REFERENCES:
patent: 4996200 (1991-02-01), Nishimura et al.
patent: 5023252 (1991-06-01), Hseih
patent: 5911993 (1999-06-01), Jian et al.
patent: 2004/0023909 (2004-02-01), Roy-Chowdhury et al.
patent: 1355254 (2002-06-01), None
patent: 04208223 (1992-07-01), None
patent: 2004026768 (2004-01-01), None
patent: WO 02/05830 (2002-01-01), None
Foroncewicz, K. M. et al. Transplantion Proceedings (2003), 35(6): 2310-2312. Anti-CD25 and tacrolimus therapy may not prevent early primary biliary cirrhosis recurrence after liver transplantation: Two case reports.
Bach, N. et al. The Mount Sinai Journal of Medicine (Sep. 2003), 70(4): 242-250. Primary biliary cirrhosis: A Mount Sinai perspective.
PTO 06-4732, Translation of Chinese Patent CN 1355254 A: “Echevaria Glauca Polysaccharides [Shilianhua Duotang]” by Ding Qing. Translated by: Schreiber Translations, Inc. (Jun. 2006).
Worman, H. J. Cirrhosis: What is Cirrhosis?. http://cpmcnet.columbia.edu/dept/gi/cirrhosis.html downloaded May 16, 2006.
U1, Wayback Machine: http://web.archive.org/web/*/http://cpmcnet.columbia.edu/dept/gi/cirrhosis.html downloaded Aug. 6, 2006.
Desmet, V.J., et al. (1994). Classification of chronic hepatitis: diagnosis, grading and staging.Hepatology19(6):1513-1520.
Friedman, S.L. (1993). The cellular basis of hepatic fibrosis. Mechanism and treatment strategies.N Engl J Med. 328(25):1828-1835.
Giladi, H., et al. (2003). Small interfering RNA inhibits hepatitis B virus replication in mice.Mol Ther. 8(5):769-776.
Pines, M., et al. (1997). Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis.J Hepatol. 27(2):391-398.
Saller, R., et al. (2001). The use of silymarin in the treatment of liver diseases.Drugs. 61(14):2035-2063.
Arai, T., et al. (2001). Effect of herb supplement on hepatic enzyme activities in ddY mice. Lab Anim. 35(3):288-291.
Chou, S.T., et al. Antimutagenic potential ofGraptopetalum paraguayenseE. Walther. 2004 Institute of Food Technologists Annual Meeting. Jul. 12-16, 2004, Session 114F, abstract 4, [retrieved Dec. 6, 2005]. Retrieved from the Internet: URL:http://ift.confex.com/ift/techprogram/paper—22911.htm, whole document.
Chung, Y.C., et al. (2005). Studies on the antioxidative activity ofGraptopetalum paraguayenseE. Walther. Food Chemistry 91:419-424.
Hsieh, C.L., et al. (2005). Inhibitory effect of some selected nutraceutic herbs on LDL glycation induced by glucose and glyoxal. J Ethnopharmacol. 102(3):357-363.
Huang, K., et al. (2005). Studies on the inhibitory effect ofGraptopetalum paraguayenseE. Walther extracts on mushroom tyrosinase. Food Chemistry 89:583-587.
Kang, T.H., et al. (2000). Antiproliferative effects of alkaloids fromSedum sarmentosumon murine and human hepatoma cell lines. J Ethnopharmacol. 70(2):177-182.
Wu, X.L., et al. (2003). Effect of compound rhodiola sachalinensis A Bor on CCl4-induced liver fibrosis in rats and its probable molecular mechanisms. World J Gastroenterol. 9(7):1559-1562.
Arai, T., et al. (2001). Effect of herb supplement on hepatic enzyme activities in ddY mice. Lab Anim. 35(3):288-291.
Chou, S. T., et al. Antimutagenic potential ofGraptopetalum paraguayenseE. Walther. 2004 Institute of Food Technologists Annual Meeting. Jul. 12-16, 2004, Session 114F, abstract 4, [retrieved Dec. 06, 2005]. Retrieved from the Internet: URL:http://ift.confex.com/ift/techprogram/paper—22911.htm, whole document.
Chung, Y. C., et al. (2005). Studies on the antioxidative activity ofGraptopetalum paraguayenseE. Walther. Food Chemistry 91:419-424.
Hsieh, C.L., et al. (2005). Inhibitory effect of some selected nutraceutic herbs on LDL glycation induced by glucose and glyoxal. J Ethnopharmacol. 102(3):357-363.
Huang, K., et al. (2005). Studies on the inhibitory effect ofGraptopetalum paraguayenseE. Walther extracts on mushroom tyrosinase. Food Chemistry 89:583-587.
Kang, T.H., et al. (2000). Antiproliferative effects of alkaloids fromSedum sarmentosumon murine and human hepatoma cell lines. J Ethnopharmacol. 70(2):177-182.
Wu, X. L., et al. (2003). Effect of compound rhodiola sachalinensis A Bor on CCI4-induced liver fibrosis in rats and its probable molecular mechanisms. World J Gastroenterol. 9(7):1559-1562.
Flood Michele
Occhiuti Rohlicek & Tsao LLP
LandOfFree
Pharmaceutical use of Graptopetalum and related plants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical use of Graptopetalum and related plants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical use of Graptopetalum and related plants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3953502