Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-07-11
1989-09-26
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548495, A61K 31405
Patent
active
048700975
ABSTRACT:
N-acylated derivatives of L-tryptophan of general formula (I), ##STR1## in which R is selected from the group consisting of: (a) a phenyl group, mono-substituted or di-substituted in the meta and para positions with halogens, linear or branched alkyl groups containing from 1 to 9 carbon atoms, the cyano group or the trifluoromethyl group, (b) a benzyloxy group, mono-substituted or di-substituted in the meta and para position with substituents selected from those indicated at (a), and (c) a benzydryloxy group. The derivatives are used in therapy, particularly for human pain relief, in the treatment of pathological conditions of the central nervous system and of pathological intestinal conditions.
REFERENCES:
Patricia L. Faris & Barry R. Komisaruk, "Evidence for the Neuropeptide Cholecstokin as an Antagonist of Opiate Analgesia", Sep. 28, 1982, Science, vol. 219, pp. 310-312.
Robert T. Jensen, Susanna W. Jones & Jerry D. Gardner "Structure-of N-Acyl Derivatives of Tryptophan that Function as a Specific Cholecystokinin Function Studies Receptor Antagonists", May 24, 1983, 1983 Elsevier Science Publishers B.V., pp. 269-277, Biochimica et Biophysica Acta 761 (1983).
"Reversing Opiate Tolerance: Proglumide Provides New Clue" American Pharmacy, vol. NS24, No. 8, Aug. 1984 508, pp. 20-21.
L. R. Watkins, I. B. Kinscheck, E. F. S. Kaufman, J. Miller, H. Frenk & D. J. Mayer, "Cholecystokinin Antagonists Selectively Potentiate Analgesia Induced by Endogenous Opiates" Brian Research, 327 (1985) 181-190.
Chiste Rolando
Makovec Francesco
Rovati Angelo L.
Rotta Research Laboratorium S.p.A.
Springer David B.
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