Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Patent
1992-10-01
1995-04-18
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
549510, 4241951, 424523, A01N 6500, C07D30500
Patent
active
054076838
ABSTRACT:
Compositions of matter are provided comprising a pharmaceutically effective amount of taxol or a tumor-active analog thereof solubilized in a pharmaceutically acceptable carrier comprising an oil having a dipole moment of between about 0.5 Debyes and about 2.0 Debyes, and preferably between about 1.6 and about 1.7 Debyes. Oils from marine organisms having an ether lipid as a major component thereof are preferred. Methods of solubilizing taxol or tumor-active taxol analogs in the pharmaceutically acceptable oils of this invention are provided comprising forming a first solution by dissolving taxol in a preliminary solvent such as an anhydrous alcohol, then adding sufficient oil to solubilize said first solution. Taxol-in-oil solutions are used to prepare oil-in-water emulsions for pharmaceutical use in anti-tumor therapy by means known to the art using known surfactants. Self-emulsifying glasses comprising taxol or tumor-active taxol analogs are also provided comprising a water-soluble, nonsurface active matrix compound and taxol-oil solutions. Emulsions are readily formed from such glasses by contacting the glass with an aqueous phase.
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Kulkosky Peter F.
Page Thurman K.
Research Corporation Technologies Inc.
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