Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-11-06
1998-01-13
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31505
Patent
active
057079960
ABSTRACT:
A liquid pharmaceutical solution having antimicrobial agent(s), an organic solvent, and an acidic or basic aqueous medium therein. Most preferred solutions include trimethoprim, sodium hydroxide, sulfadiazine, N-methylpyrrolidone and water. The present invention is also directed toward making these solutions. A most preferred composition includes: trimethoprim in an amount of about 40 mg/ml of liquid pharmaceutical solution; sulfadiazine in an amount of about 200 mg/ml of liquid pharmaceutical solution; N-methylpyrrolidone in an amount of about 514 mg/ml of liquid pharmaceutical solution, sodium hydroxide in an amount of about 30 mg/ml of liquid pharmaceutical solution and water. Methods of making the pharmaceutical solution preferably include combining the following in any order: trimethoprim, N-methylpyrrolidone, sulfadiazine, and an acidic or basic aqueous medium. Other additives, such as antioxidants and preservatives, can also be added to the liquid pharmaceutical solution.
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Fay Zohreh
Macleod Pharmaceuticals, Inc.
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