Pharmaceutical soft capsules containing lysine clonixinate and a

Details Pharmaceutical soft capsules containing lysine clonixinate and a Pharmaceutical soft capsules containing lysine clonixinate and a

1994-12-12

1997-05-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, 424456, A61K 948

Patent

active

056268726

ABSTRACT:
A soft gelatin capsule with a filling including lysine clonixinate as an active ingredient and in a hydrophilic matrix and with a shell comprising gelatin, a plasticizer and sorbitol, wherein the plasticizer in many instances will be glycerol but may comprise the sorbitol alone. The presence of sorbitol in the gelatin capsule of a lysine clonixinate dosage form imparts unexpectedly good drug release and stability thereto.

REFERENCES:
patent: 3973027 (1976-08-01), Ferrari
patent: 4797286 (1989-01-01), Thakkar et al.
patent: 5128364 (1992-07-01), Girard et al.
patent: 5273760 (1993-12-01), Oshlack et al.
patent: 5389650 (1995-02-01), Frenette et al.

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