Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Elemental fluorine or fluorine compound
Patent
1987-10-13
1989-07-18
Clingman, A. Lionel
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Elemental fluorine or fluorine compound
A01N 5910
Patent
active
048492213
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a novel pharmaceutical product containing a mixture of benzoic acid, phenol and an alkali fluoride in an aqueous or aqueous-alcohol solution, optionally in the presence of other usual additives for pharmaceutical preparations in liquid or semi-liquid form, and its use for controlling herpes-virus-caused diseases in the human.
Herpes-virus-caused diseases in the human generally induce a more or less pronounced formation of blisters, and especially on human mucous membranes they cause the formation of sometimes very painful or extremely itchy blisters. A particularly well known form of such diseases is herpes simplex.
A product that contains both benzoic acid and phenol and sodium fluoride is on the market and is used highly diluted with water as a disinfectant for the area of the mouth. Unexpectedly, mixtures of benzoic acid, phenol and an alkali fluoride, preferably sodium fluoride, in an aqueous or aqueous-alcohol solution, which optionally contains other usual additives for pharmaceutical preparations in liquid or semi-liquid form, in a form not highly diluted with water, are suitable for rapid and effective control of herpes-virus-caused diseases in the human, in particular for external treatment of the diseased areas of the skin, especially mucous membrane areas.
The individual components are known in numerous pharmaceutical preparations. For instance, benzoic acid and phenol are used as antiseptics, and sodium fluoride is used for caries prevention.
The pharmaceutical product according to the invention for controlling herpes-virus-caused diseases in the human is characterized in that for 100 g of end product, it contains, besides water or water-alcohol as a solvent and besides typical additives for pharmaceutical preparations in liquid or semi-liquid form, from 0.1 to 0.5 g of the alkali fluoride, in particular sodium fluoride, preferably from 0.2 to 0.4 g of benzoic acid, from 0.6-0.8 g of phenol, and from 0.2 to 0.4 g of the alkali fluoride.
EXAMPLE 1
100 g of an aqueous solution contain 0.65 g of a 1:5 solution of benzoic acid in ethyl alcohol, 0.73 g of phenol and 0.22 g of sodium fluoride. The product additionally contains 5.88 g of menthol oil, 1.2 g of 01 carbophylli, 1.63 g of methyl salicylate and 0.74 g of p-ethyl hydroxybenzoate.
The ingredients are intimately mixed and poured into containers having a stopper of a kind such that the stopper can be used to apply the product drop by drop to the affected areas.
EXAMPLE 2
100 g of an aqueous solution contain 2.4 g of a 1:5 solution of benzoic acid in ethyl alcohol (0.4 g of benzoic acid and 2.0 g of 96% alcohol), 1 g of phenol and 0.4 g of sodium fluoride. It contains no additives, for improving the odor, for example. The ingredients are processed as in example 1.
1. A pharmaceutical product containing a mixture of benzoic acid, phenol and an alkali fluoride, in an aqueous or aqueous-alcohol solution, optionally in the presence of other usual additives for pharmaceutical preparations, in liquid or semi-liquid form, for the topical treatment of herpes virus efflorescences.
2. A pharmaceutical product as defined by claim 1, characterized in that the alkali fluoride is sodium fluoride.
3. A pharamaceutcal product as defined by claim 1, characterized in that 100 g of the product contain from 0.1 to 0.5 g of benzoic acid, from 0.5 to 1.0 g of phenol and from 0.1 to 0.5 g of the alkali fluoride.
4. A phamaceutical product as defined by claim 3, characterized in that 100 g of the product contains from 0.2 to 0.4 g of benzoic acid, 0.6 to 0.8 g of phenol and 0.2 to 0.4 g of the alkali fluoride.
5. A method for the topical treatment of herpes simplex efflourescences, characterized in that a product defined by claim 1 is applied to the efflorescence once or or a plurality of times.
DESCRIPTION
EXAMPLE 1
100 g of an aqueous solution contain 0.65 g of a 1:5 solution of benzoic acid in ethyl alcohol, 0.73 g of phenol and 0.22 g of sodium fluoride. The product additionally contains 5.88 g of menthol oil, 1.2 g of 01 c
REFERENCES:
patent: 3337412 (1967-08-01), Elbreder
patent: 4363794 (1982-12-01), Ochiai et al.
patent: 4568540 (1986-02-01), Asano et al.
patent: 4624851 (1986-11-01), Revici
Rote Liste 1985 (with translation).
Clarke Dennis P.
Clingman A. Lionel
Thompson Willie J.
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