Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1982-05-10
1984-06-19
Rosen, Sam
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424274, 424275, 424308, 424309, 424317, 424319, A61K 3556
Patent
active
044552980
ABSTRACT:
The invention concerns novel pharmaceutical preparations containing (A) an extract of the mollusc Perna canaliculus, a mussel which is found on the shores of New Zealand, and (B) a pharmaceutically active substance, especially medicaments having anti-phlogistic, antipyretic and/or analgetic action, which, when taken per se, may cause as a side effect irritation of the gastro-intestinal mucosae and possibly the formation of ulcers. The addition of a mollusc extract according to (A) to the said medicaments has a gastro-protective action, in that the occurence of the said side effects is prevented or diminished. The component (A) is preferably used as a dry powder of the whole of the flesh of the mollusc or a dry powder obtained from the gonads thereof. In a typical preparation according to the invention an extract of the gonads is e.g. combined with acetyl-salicylic acid. The preparations may contain the 2 components in one and the same dosage unit form, e.g. a capsule or in 2 different ones, e.g. a capsule and a tablet.
The invention also includes a method for preventing, alleviating or treating gastro-intestinal irritation or ulcer formation by administering an effective amount of the mollusc extract as defined under A.
REFERENCES:
Cullen et al.-New Zealand Med. J., Mar. 12, 1975, pp. 260-261.
Highton et al.-New Zealand Med. J., Mar. 12, 1975, pp. 261-262.
Croft John E.
McFarlane Stuart J.
Kolodny Joseph G.
Rosen Sam
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