Drug – bio-affecting and body treating compositions – Digestive system regulator containing solid synthetic...
Patent
1989-10-12
1992-02-11
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Digestive system regulator containing solid synthetic...
424690, 424 7826, 424 7817, A61K 3178, A61K 3308
Patent
active
050874470
ABSTRACT:
The invention relates to a new pharmaceutical preparation of high acid-binding capacity, of delayed effect, of increased bioavailability for neutralization of gastric acid and optionally to other pharmaceutical preparations acting in the gastrointestinal tract, first of all of laxative effect by mixing 100 parts by mass of a powdered basic magnesium compound or the powdered mixture of basic magnesium compounds and basic aluminium compounds with 2-2500 parts of a dry or swollen organic acid of polymeric character and therapeutically acceptable, e.g. cellulose-glycolic acid, starch-glycolic acid or polymer acrylic and/or methacrylic acid, letting this powdered mixture to stand for 1-24 hours at the temperature of 20.degree.-80.degree. C. after addition of 50-500 parts by mass of water and forming tablets or other pharmaceutical preparations, optionally after addition of 5-60 parts by mass of smoothing agents and/or other pharmaceutical excipients, or transforming the mixture containing the basic active ingredients and the polymeric organic acid in liquid suspension by adding water and optionally excipients.
REFERENCES:
patent: 3326755 (1967-06-01), Sheth
Plachy Janos
Racz Istvan
Szentmiklost Peter
Dubno Herbert
Fay Zohreh
Myers Jonathan
Waddell Frederick E.
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