Pharmaceutical preparations for treating inflammatory diseases

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Peroxide or compositions of or releasing gaseous oxygen or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S049000, C424S405000, C514S885000, C514S886000, C514S887000

Reexamination Certificate

active

07955623

ABSTRACT:
The present invention refers to a pharmaceutical preparation for treating inflammatory diseases and microbial infections comprising a pharmaceutically effective amount of ozone and at least one monomeric amino acid having an oxidation-sensitive side chain, or at least one ozonized monomeric amino acid having an oxidation-sensitive side chain.Also described is the use of a preparation as described before for providing a medicament for treating inflammatory diseases, microbial infections and for immune modulation. The pharmaceutical preparation according to the invention is particularly useful in the treatment of oral inflammations.

REFERENCES:
patent: 6258384 (2001-07-01), Stanley et al.
patent: 7172426 (2007-02-01), Lynch et al.
patent: 2003/0211465 (2003-11-01), Mundschenk et al.
patent: 2004/0220264 (2004-11-01), Yu et al.
Huth et al. (J Dent Res May 2007, 86(5), 451-456).
Kotiaho et al. (J Am Soc Mass Spectrom 2000, 11, 526-535).
Mudd et al. (Atmospheric Environment 1969, 3(6), 669-682).
Read, New Scientist, 1989; p. 40; 1 page.
Grinwald, Chemokine Research Trends, 2007, Nova Publishers; p. 12; 1 page.
Ghosh, Handbook of transcription factor NF-kappaB, 2007, CRC Press; pp. 195-196; 3 pages.
Arita, M., et al., Microbicidal efficacy of ozonated water againstCandida albicansadhering to acrylic denture plates.Oral Microbiology and Immunology. vol. 20 pp. 206-210 (2005).
Bartold, P.M., and Narayanan, A.S., Molecular and cell biology of healthy and diseased periodontal tissues.Periodontology. vol. 40 pp. 29-49 (2006).
Baysan, A., and Lynch, E., Effect of ozone on the oral microbiota and clinical severity of primary root caries.American Journal of Dentistry. vol. 17, No. 1. pp. 56-60 (2004).
Bonizzi, G., and Karin, M., The two NF-κβ activation pathways and their role in innate and adaptive immunity.Trends in Immunology. vol. 25, No. 6 pp. 280-288 (2004).
Capello, C., et al., Ozonized Low Density Lipoprotein (ozLDL) Inhibits NF-κβ and IRAK-1-Associated Signaling.Arteriosclerosis, Thrombosis and Vascular Biology, pp. 226-232 (2007).
Cataldo, Franco, On the action of ozone on proteins.Polymer Degradation and Stability. vol. 82 pp. 105-114 (2003).
Chen, G., and Goeddel, D.V., TNF-R1 Signaling: A Beautiful Pathway.Science. vol. 296 pp. 1634-1635 (2002).
Ebensberger, U., et al., PCNA-expression of cementoblasts and fibroblasts on the root surface after extraoral rinsing for decontamination.Dental Traumatology. vol. 18 pp. 262-266 (2002).
Filippi, A., The effects of ozonized water on epithelial wound healing.Deutsche Zahnärztliche Zeitschrift. vol. 56 pp. 104-108 (2001).
Gamonal, J., et al., Levels of Interleukin-1β, -8, and -10 and RANTES in Gingival Crevicular Fluid and Cell Populations in Adult Periodontitis Patients and the Effect of Periodontal Treatment.Journal of Periodontology. vol. 71, No. 10 pp. 1535-1545 (2000).
Graves, D. T., et al., Periodontal disease: bacterial virulence factors, host response and imact on systemic health.Current Opinion in Infectious Diseases. vol. 13 pp. 227-232 (2000).
Haddad, E.-B., et al., Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-κb in rat lung: inhibition by corticosteroids.FEBS Letters. vol. 379 pp. 265-268 (1996).
Honda, T., et al., Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions.Clinical and Experimental Immunology. vol. 144 pp. 35-40 (2006).
Huth, K.C., et al., Effect of ozone on oral cells compared with established antimicrobials.European Journal of Oral Sciences. vol. 114 pp. 435-440 (2006).
Laskin, D.L., et al., Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-κβ and STAT-1 in ozone-induced nitric oxide production and toxicity.Molecular and Cellular Biochemistry. vol. 234-235 pp. 91-98 (2002).
Lin, C., et al., Effects of Root-End Filling Materials and Eugenol on Mitochondrial Dehydrogenase Activity and Cytotoxicity to Human Periodontal Ligament Fibroblasts.Journal of Biomedical Materials Research Part B Applied Biomaterials. vol. 71B pp. 429-440 (2004).
Madianos, P.N., et al., Generation of inflammatory stimuli: how bacteria set up inflammatory responses in the gingiva.Journal of Clinical Periodontology. vol. 32 pp. 57-71 (2005).
Márton, I.J., and Kiss, C., Protective and destructive immune reactions in apical periodontitis.Oral Microbiology and Immunology. vol. 15 pp. 139-150 (2000).
Nagayoshi, M., et al., Antimicrobial Effect of Ozonated Water on Bacteria Invading Dentinal Tubules.Journal of Endodontics. vol. 30, No. 11 pp. 778-781 (2004).
Nagayoshi, M., et al., Efficacy of ozone on survival and permeability of oral microorganisms.Oral Microbiology and Immunology. vol. 19 pp. 240-246 (2004).
Nair, P.N.R. Pathogenesis of Apical Periodontitis and the Causes of Endodontic Failures.Critical Reviews in Oral Biology and Medicine. vol. 15, No. 6 pp. 348-381 (2004).
Nichols, T.C., et al., Role of Nuclear Factor-Kappa B (NF-κβ) in Inflammation, Periodontitis, and Atherogenesis.Annals of Periodontology. vol. 6, No. 1 pp. 20-29 (2001).
Page, S., et al., 4-Hydroxynonenal Prevents NF-κβ Activation and Tumor Necrosis Factor Expression by Inhibiting IκB Phosphorylation and Subsequent Proteolysis.The Journal of Biological Chemistry. vol. 274, No. 17 pp. 11611-11618 (1999).
Paraskeva, P., and Graham, N.J.D., Ozonation of Municipal Wastewater Effluents.Water Environment Research. vol. 74, No. 6. pp. 569-581 (2002).
Restaino, L., et al., Efficacy of Ozonated Water against Various Food-Related Microorganisms.Applied and Environmental Microbiology. vol. 61, No. 9 pp. 3471-3475 (1995).
Sabeti, M., et al., Detection of Receptor Activator of NF-κβ Ligand in Apical Periodontitis.Journal of Endodontics. vol. 31, No. 1 pp. 17-18 (2005).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pharmaceutical preparations for treating inflammatory diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical preparations for treating inflammatory diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical preparations for treating inflammatory diseases will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2693835

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.