Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1981-02-20
1983-10-04
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
A61K 3114
Patent
active
044078242
ABSTRACT:
The invention relates to pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids, in particular compounds of the formula ##STR1## wherein R.sub.1 is a group of the formula ##STR2## wherein X.sub.1 and X.sub.2 are hydrogen and X.sub.3 is isobutyl, or X.sub.1 and X.sub.3 are hydrogen and X.sub.2 is benzoyl, or X.sub.1 is hydrogen, X.sub.2 is chlorine, and X.sub.3 is 3-pyrrolin-1-yl, or X.sub.1 is hydrogen, X.sub.2 is a group of the formula --CH.dbd.CH--C(OCH.sub.3).dbd.CH--X.sub.4, and X.sub.3 together with X.sub.4 are a bond, and R.sub.2 is methyl, or X.sub.2 and X.sub.3 are hydrogen and X.sub.1 is 2,6-dichloroanilino, and R.sub.2 is hydrogen, or R.sub.1 is a group of the formula ##STR3## wherein X.sub.5 is the common bond with the methine group in formula I, X.sub.6 and X.sub.7 are hydrogen, X.sub.8 is p-methylbenzoyl, Y is a nitrogen atom, and X.sub.9 is a methyl group, or X.sub.5 is a methyl group, X.sub.6 is a common bond with the methine group in formula I, X.sub.7 is a group of the formula --CH.dbd.C(OCH.sub.3)--CH.dbd.CH--X.sub.10, X.sub.8 together with X.sub.10 are a bond, Y is a nitrogen atom and X.sub.9 is p-chlorobenzoyl, or X.sub.5 is a methyl group, X.sub.6 is the common bond with the methine group in formula I, X.sub.7 is a group of the formula --CH.dbd.C(F)--CH.dbd.CH--X.sub.11, X.sub.8 together with X.sub.11 are a bond, Y is a carbon atom and X.sub.9 is (p-methanesulfinylphenyl)methylene, and R.sub.2 is hydrogen, and each of R.sub.3, R.sub.4 and R.sub.5 independently is hydrogen, an aliphatic radical, or two of R.sub.3, R.sub.4 and R.sub.5 together are a bivalent aliphatic radical, unsubstituted or substituted or interrupted by aza, oxa or thia, with the proviso that at least one of R.sub.3, R.sub.4 and R.sub.5 is different from hydrogen, optionally in the form of an isomer, together with conventional carriers and/or excipients for topical application. The invention also relates to the production of these preparations and also to novel compounds of the formula I and a process for their production. The compounds of the formula I are suitable for use as anti-inflammatory agents and/or analgesics for topical application.
REFERENCES:
patent: 3161654 (1964-12-01), Shen
patent: 3385886 (1968-05-01), Nicholson et al.
patent: 3558690 (1971-01-01), Sallman et al.
patent: 3637767 (1972-01-01), Alvarez
patent: 3641040 (1972-02-01), Carney et al.
patent: 3641127 (1972-02-01), Farge et al.
patent: 3647858 (1972-03-01), Hinkley et al.
patent: 3752826 (1973-08-01), Carson
Ciba-Geigy Corporation
Feit Irving N.
Friedman Stanley J.
LandOfFree
Pharmaceutical preparations for topical application which contai does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical preparations for topical application which contai, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical preparations for topical application which contai will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-973230