Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-10-25
1997-11-11
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 3116
Patent
active
056864949
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/JP94/00721 filed Apr. 28, 1994.
This invention relates to pharmaceutical preparations for the amelioration of nonulcer dyspepsia (NUD) (or epigastric dysfunction)-related complaints.
BACKGROUND OF THE INVENTION
Among ailments conventionally diagnosed as chronic gastritis, chronic symptoms may occur in the epigastric area despite the absence of morphological changes in the digestive system has recently been given a concept of "non-ulcer dyspepsia (NUD)" which occurs due to an abnormal motility of the digestive tract.
Epigastric dysfunction related complaints with the absence of morphological changes in the digestive tracts, such as gastric heaviness, nausea, vomiting, anorexia, abdominal distension, heartburn, epigastric pain, and eructation, are called "digestive system or NUD-related complaints". Though therapeutic drugs for gastritis have been generally used for the treatment in patients with such symptoms, their actions are not satisfactory. In recent years, digestive tract motility regulating agents such as cisapride (a digestive tract motility activation regulating agent) and, trimebutine maleate (a digestive tract motility adjusting agent) became commonly used in the field of the treatment of such complaints, but their efficacy are not sufficient.
With the aim of providing a digestive tract motility regulating agent which is superior to the aforementioned known agents, the inventors of the present invention have conducted extensive studies and found that an aminobenzamide compound or a salt thereof which is known to be useful as an anti-peptic ulcer agent having an excellent antiulcer effect (JP-A-55-31027, JP-A-56-18947, JP-A-61-267542, EP-A-9608, EP-A-185368, and U.S. Pat. Nos. 4,297,357 and 4,985,595; the term "JP-A" as used herein means an "unexamined published Japanese patent application") also has a digestive tract motility regulating action and is useful as an agent for ameliorating NUD (or epigastric dysfunction complaints) and as a digestive tract motility regulating agent. The present invention has been accomplished on the basis of this finding.
DISCLOSURE OF THE INVENTION
The present invention relates to a pharmaceutical preparation for the amelioration of NUD (or epigastric dysfunction)-related complaints, which contains as an active ingredient an aminobenzamide compound represented by the following formula (1) or a salt thereof: ##STR2## wherein each of R.sup.1 and R.sup.2 is independently a lower alkoxyl group; R.sup.3 is a hydrogen atom, a lower acyl group, a lower alkyl group, a lower alkoxycarbonyl group or a group represented by the formula --X--SO.sub.3 M where X is a lower alkylene group and M is an alkali metal or an alkaline earth metal; R.sup.4 is a hydrogen atom, a halogen atom or a lower alkoxyl group; R.sup.5 is an amino group, a morpholino group or a lower alkylamino group, where the alkyl moiety of the lower alkylamino group may have a hydroxyl group; and n is an integer of 1 to 6.
The present invention further relates to a pharmaceutical preparation for the amelioration of NUD (or epigastric dysfunction complaints) of chronic gastritis, which contains as an active ingredient an aminobenzamide compound represented by formula (1) or a salt thereof;
a pharmaceutical preparation for the amelioration of NUD (or epigastric dysfunction complaints) chronic gastritis, which contains as an active ingredient an aminobenzamide compound represented by formula (1) or a salt thereof;
a pharmaceutical preparation for the treatment of digestive system indefinite complaints, which contains as an active ingredient an aminobenzamide compound represented by formula (1) or a salt thereof; and
a pharmaceutical preparation for the treatment of non-ulcer dyspepsia, which contains as an active ingredient an aminobenzamide compound represented by formula (1) or a salt thereof.
The present invention further relates to a pharmaceutical preparation for the regulation of digestive tract motility, which contains as an active ingredient an aminobenzamide compound re
REFERENCES:
patent: 4985595 (1991-01-01), Miki et al.
Asano Masahide
Furuhama Kazuhisa
Hatanaka Satoshi
Kawarabayashi Keiko
Nakajima Kazuhiko
Daiichi Pharmaceutical Co. Ltd.
Henley III Raymond
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