Pharmaceutical preparations containing a polymeric agent for rel

Details Pharmaceutical preparations containing a polymeric agent for rel Pharmaceutical preparations containing a polymeric agent for rel

1979-11-29

1981-11-03

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

A61K 3174

Patent

active

042985951

ABSTRACT:
An intestinal anti-inflammatory preparation comprising a polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed. The polymeric agent comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymer's azo bonds undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.

REFERENCES:
patent: 3862312 (1975-01-01), Rimington et al.

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