Pharmaceutical preparations and methods for inhibiting tumors

Details Pharmaceutical preparations and methods for inhibiting tumors Pharmaceutical preparations and methods for inhibiting tumors

2005-09-30

2010-02-02

Harris, Alana M. (Department: 1643)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S012200, C514S014800, C514S015800, C514S017400, C514S018700, C530S300000, C530S324000, C530S326000, C530S330000, C530S350000

Reexamination Certificate

active

07655631

ABSTRACT:
The invention provides pharmaceutical compositions and method for inhibiting growth of prostatic adenocarcinoma, stomach cancer, breast cancer, endometrial, ovarian or other cancers of epithelial secretion, or benign prostate hyperplasia (BPH) In one embodiment the pharmaceutical composition includes human rHuPSP94, antigenic portions thereof, and functionally equivalent polypeptides thereof. In another embodiment, the pharmaceutical composition includes a mixture of human rHuPSP94, antigenic portions thereof, and functionally equivalent polypeptides thereof and an anticancer drug which may be administered in an appropriate dosage form, dosage quantity and dosage regimen to a patient suffering from, for example of prostatic adenocarcinoma, stomach cancer, breast cancer, endometrial, ovarian or other cancers of epithelial secretion, benign prostate hyperplasia, or (BPH) gastrointestinal cancer. The anticancer drug of the latter mixture may be one selected from the group of drugs including mitomycin, idarubicin, cisplatin, 5-fluoro-uracil, methotrexate, adriamycin, daunomycin, taxol, taxol derivative, and mixtures thereof.

REFERENCES:
patent: 4764502 (1988-08-01), diZerega
patent: 5102807 (1992-04-01), Burger et al.
patent: 5428011 (1995-06-01), Sheth et al.
patent: 5994298 (1999-11-01), Tsai et al.
patent: 6319894 (2001-11-01), Tracey et al.
patent: WO 93/25224 (1993-12-01), None
patent: WO 93 25224 (1993-12-01), None
patent: WO 00/55174 (2000-09-01), None
Bowie et al, Science, 247:1306-1310, 1990.
Burgess et al, J. Cell Biology, 111: 2129-2138, 1990.
Lazar et al, Molecular and Cellular Biology, 8:1247-1252, 1988.
Ulvsback, et al.,Biochem. Biophys. Res. Comm., 164:1310, 1989.
Green, et al.,Biochem. Biophys. Res. Comm., 167:1184, 1990.
Yang, et al.,J.Urol., 160:2240, 1998.
Garde, et al.,Prostate, 22:225, 1993.
Lokeshwar, et al.,Cancer Res., 53:4855, 1993.
Todaro, G.J., Green, H.,J.Cell Biol., 17:299-313, 1963.
Puck, T.T., et al.,J. Exp. Med., 108:945-956, 1958.
Buckholz, R.G., Gleeson, M.A.G.,Biotechnology, 9:1067-1072, 1991.
Cregg, J.M., et al.,Biotechnology, 11:905-910, 1993.
Sreekrishna, K., et al.,J. Basic Microbiol., 28:265-278, 1988.
Wegner, G.H.,FEMS Microbiology Reviews, 87:279-284, 1990.
Smith, T.F., Waterman, M.S.,Ad. Appln. Math., 2:482-489, 1981.
Needleman, S.B., Wunsch, C.D.,J. Mol. Biol., 48:443-453, 1970.
J.W. Xuan, et al.,Recombinant PSP94(Prostate Secretory Protein of 94 Amino Acids)Demonstrates Similar Linear Epitope Structure as Natural PSP94 Protein, Journal of Cellular Biochemistry, 63:61-73, 1996.
C.G. Linard,Correct Processing and Secretion of a Human Prostatic Secretory Protein(PSP94)in Escherichia coli, Gene., vol. 73, pp. 479-487, 1988.
M.Baijal-Gupta, et al.,Prostatic Secretory Protein(PSP94)Expression in Human Female Reproductive Tissues, Breast and in Endometrial Cancer Cell Line, Journal of Endocrinology, vol. 165, pp. 425-433, 2000.
S.V. Garde, et al.,Prostate Secretory Protein(PSP94)Suppresses the Growth of Androgen-Independent Prostate Cancer Cell Line(PC3)and Xenografts by Inducing Apoptosis, The Prostate, 38:118-125, 1999.
Mbikay, M., et al. (DNA 6(1):23-29, 1987 (Gene Bank Accession No. AAA36635).
Makinen, M., et al. (Eur. J. Biochem. 264(2):407-414, 1999 (Gene Bank Accession No. CAB39325).
Akiyama, K., et al., Nippon Hoigaku Zasshi 39(2), pp. 181-186, 1985 (Gene Bank Accession No. 1209281A).
Xuan, J.W., et al., J. Cell. Biochem., vol. 63, pp. 61-73, 1996.
Linard, C.G., et al., vol. 73, pp. 479-488, 1988.
Baijal-Gupta, M., et al., J. Endocrinology, vol. 165, pp. 425-433, 2000.
Garde, S.V., et al., Prostate, vol. 38, pp. 118-125, 1999.
Kele, P., et al., 26th European Peptide Symposium, J. Pept. Sci., vol. 6, Abstract S172, 2000.
Bowie, et al., Science, 247: 1306-1310, 1990.
Burgess, et al., J. Cell Biology, 111:2129-2138, 1990.
Lazar, et al., Molecular and Cellular Biology, 8: 1247-1252, 1988.
Nolet, S. et al., Biochimica et Biohysica Acta, 1089: 247-249, 1991.
Xuan, J.W. et al., DNA & Cell Biology, 16: 627-638, 1997.
Xuan, J.W. et al., Journal of Cellular Biochemistry 65: 172-185, 1997.

Affiliated with

Also associated with

Rating

Pharmaceutical preparations and methods for inhibiting tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical preparations and methods for inhibiting tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical preparations and methods for inhibiting tumors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4167858