Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1987-08-06
1989-10-17
Ford, John M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
546347, 546290, 546321, C07D21355, C07D21368, C07D21320, C08B 3704
Patent
active
048748501
ABSTRACT:
A pharmaceutical preparation is disclosed which is made up of a micelle or a vesicle each consisting of a cationic tenside with a monovalent ion and a hydrophobic cyclic or linear peptide, dispersed in a solvent whose pH value lies between pH 7-pH 8, the critical micellization concentration (cmc) lying in the range of 1.0 . 10.sup.-7 to 7.0 . 10.sup.-5 mol/liter. The preparation disclosed have in particular the advantage that by the increasing of the hydrophobicity of the alkyl or aryl chain or the radical at the N.sup.+ tenside both the membrane permeability is increased and furthermore the pharmaceutical active substance, in particular linear and cyclic tyrocidines (A-E), can be transferred actively into the cytosol. They thus act on the transcription level. In addition, linear and cyclic tyrocidines in particular have antiviral effects.
REFERENCES:
Petrova, Chemical Abstracts, vol. 81, entry 6792d (1974).
Hoffmann et al., Chemical Abstracts, vol. 88, entry 12410p (1978).
Zana et al., Chemical Abstracts, vol. 105, entry 30563q (1986).
Ford John M.
Medice Chem.-Pharm. Fabrik Putter GmbH & Co.
LandOfFree
Pharmaceutical preparations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical preparations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical preparations will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1744425