Pharmaceutical preparations

Details Pharmaceutical preparations Pharmaceutical preparations

1987-08-06

1990-01-16

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544232, 544408, 544410, C07D24119, C07D24124

Patent

active

048944548

ABSTRACT:
The synthesis of 4-, 4-(1,1)- and 3,5- substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10.sup.-5 -10.sup.-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.

REFERENCES:
patent: 4013643 (1977-03-01), Nysted
Burrows et al, J. Chem. Soc. Faraday Trans. 1, 1982, 78, 947-955, "Dodecylpyrazinium Halides . . . ".
Burrows et al, Chem. Abst., vol. 96-223731x, (1982), "Dodecylpyrazinium halides".

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