Pharmaceutical preparation with an active substance of low solub

Details Pharmaceutical preparation with an active substance of low solub Pharmaceutical preparation with an active substance of low solub

1985-12-30

1988-02-23

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 514781, 514786, 514789, A61K 900, A61K 966

Patent

active

047271094

ABSTRACT:
A pharmaceutical preparation having an active substance of low solubility in water and gastric juices that has an initially liquid carrier system consisting of a hydrophilic component, a hydrophobic component and a solubilizer. The solvent mixture contains 9 to 90 parts by weight of solubilizer and 90 to 5 parts by weight of a hydropholic component, such as polyethylene glykol, 1,2-propylene glykol, 1,3-butanediol, 1,4-butanediol, 1,2-propanediol, glycerol, mannitol, sorbitol or polyoxyethylene polyoxypropylene copolymerisate or mixtures of such substances, and 40 to 1 parts by weight of an oleophilic component, such as natural and/or semisynthetic vegetable or animal oils or synthetic oils, such as neutral oil or waxes. The active substance is dissolved in the carrier system or dispersed in a stable way and for an oral application, is filled into drug capsules made of gelatine. In order to achieve a delayed release of the active substance (delayed-action effect), an adjuvant that is soluble in the carrier system is also added to the carrier system in the amount of up to 10 parts by weight, preferably 2 to 5 parts by weight that, after the dissolving of the capsule wall, develops in contact with the gastric juices a renewing permeable membrane. Suitable adjuvants are ethylcellulose, cellulose acetate phthalate, hydroxypropylmethylcellulose phthalate and vinylacetate crotonic acid copolymers or mixtures thereof.

REFERENCES:
patent: 3197369 (1965-07-01), Widmann et al.
patent: 4177254 (1979-12-01), Khan et al.
patent: 4198391 (1980-04-01), Grainger
patent: 4572833 (1986-02-01), Pedersen et al.
patent: 4574080 (1986-03-01), Roswall et al.
patent: 4595583 (1986-06-01), Eckenhoff et al.
patent: 4605548 (1986-08-01), Ushiyama et al.

Affiliated with

Also associated with

Rating

Pharmaceutical preparation with an active substance of low solub does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical preparation with an active substance of low solub, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical preparation with an active substance of low solub will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-603259