Pharmaceutical preparation possessing antinicotine effect and me

Tobacco – Tobacco or tobacco substitute product or component part thereof – Compositions – e.g. – smoking or chewing mixture or medium

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131270, 426 3, 428 48, 428197, A24B 4700, B32B 314

Patent

active

049710796

ABSTRACT:
A pharmaceutical preparation, in a chewing gum carrier, possessing an antinitocine effect which comprises a biologically resorbable polymeric vehicle containing a cation-exchange group and modified thereat by an antinicotine-action action alkaloid in the following proportions thereof, percent by mass: antinitocine-action alkaloid 2.5-40.0 polymeric vehicle the balance. The method of producing the preparation comprises reacting a biologically resorbable polymeric vehicle containing a cation-exchange group with an antinicotine-action alkaloid in an aqueo-organic medium at a volume ratio of the aqueous and organic phases of 1-15:1-24 respectively and at a temperature within the range of from 8.degree. to 22.degree. C.

REFERENCES:
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patent: 3877468 (1975-04-01), Lichtneckert et al.
patent: 3901248 (1975-08-01), Lichtneckert et al.
patent: 4195645 (1980-04-01), Bradley
Chem. and Pharm. J.; "Anabosine . . . "; vol. XII, No. 2; pp. 149-152; Nasirou et al.; 1978.
"Medical Preparations"; pp. 206-207; Urvantsev; Nauka; Tekhnika Pub.; Minsk; 1973.
Chem. Abst., vol. 79; 83451c; "Sub. for Tob. Smoking"; 1973; Ferno et al.
"Org. Chem."; Feiser and Feiser; pp. 826-827; 1956; Reinhold Pub. Co.; NY.

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