Pharmaceutical preparation for the maturation of prothymocytes

Details Pharmaceutical preparation for the maturation of prothymocytes Pharmaceutical preparation for the maturation of prothymocytes

1991-01-16

1993-08-17

Low, Christopher S. F.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 514 12, 514 2, 514 8, 514 21, 530351, 530350, 435975, 43525233, 935 73, A61K 4500, C07K 1300, C07K 1526

Patent

active

052367061

ABSTRACT:
The invention concerns a pharmaceutical preparation comprising the 25K IgE-binding factor (25K IgE-bf) and interleukin-1 (IL-1), and the use of said pharmaceutical preparation for the stimulation of the maturation of prothymocytes, e.g. for the treatment of T cell immunodeficiencies and prothymocyte leukemias.

REFERENCES:
patent: 4808611 (1989-02-01), Cosman
patent: 5135851 (1992-08-01), Kojander
Mossalayi et al. (Mar. 1, 1990) J. Exp. Med. 171(3):959-964.
Mossalayi et al. (May 15, 1990) Blood 75(10):1924-1927.
Mossalayi et al. (1985) J. Immunology 134(4):2400-2404.
Lecron et al. (1989) Exp. Hematol. 17:785-790.
Vercelli et al. (1988) J. Exp. Med. 167:1406-1416.
TeVelde et al. (Apr. 15, 1990), J. Immunology 144:3052-3059.

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