Pharmaceutical preparation for percutaneous absorption

Details Pharmaceutical preparation for percutaneous absorption Pharmaceutical preparation for percutaneous absorption

1992-12-22

1995-05-09

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 514946, 514947, A61F 1302

Patent

active

054137764

ABSTRACT:
The present invention provides a pharmaceutical preparation for percutaneous absorption comprising a drug-impermeable substrate having provided thereon an adhesive layer comprising a drug and a drug dissolution aid, characterized in that said adhesive is composed of a copolymer essentially consisting of 5 to 35 wt % of N-vinyl-2-pyrrolidone and 65 to 95 wt % of an acrylic acid ester, 3 to 30 wt % of a homopolymer of N-vinyl-2-pyrrolidone is contained in said adhesive layer as the drug dissolution aid, and said drug is a hydrophilic drug having a saturation solubility of 6 to 50 wt % to N-vinyl-2-pyrrolidone. Where the hydrophilic drug is Piroxicam, it is preferred to use a polyoxyethylene alkyl ether and/or a fatty acid alkylolamide as an absorption enhancer in combination.

REFERENCES:
patent: 4455146 (1984-06-01), Noda et al.
patent: 4751087 (1988-06-01), Wick
patent: 4781926 (1988-11-01), Hyon et al.
patent: 4789667 (1988-12-01), Makino et al.
patent: 4906475 (1990-03-01), Kim
patent: 5032402 (1991-07-01), Digenis

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