Pharmaceutical preparation controlled to release medicinal activ

Details Pharmaceutical preparation controlled to release medicinal activ Pharmaceutical preparation controlled to release medicinal activ

1995-03-10

1998-03-10

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424463, 424476, 424479, 424482, 424494, 424497, 424498, 427 214, A61K 932, A61K 936, A61K 942

Patent

active

057258805

ABSTRACT:
A pharmaceutical preparation for oral administration which is controlled to release a medicinal active ingredient at a targeted site in the intestinal tract comprising (a) a core containing a medicinal active ingredient and (b) a press-coated layer comprising an enteric polymer, said layer being provided around the core. In the pharmaceutical preparation of the present invention, the medicinal active ingredient is not released during residence in the stomach and, after discharged from the stomach, until reaching a targeted site in the intestine, and thereafter is quickly released, so that the medicinal active ingredient is efficiently delivered to the targeted site in the intestinal tract.

REFERENCES:
patent: 3325365 (1967-06-01), Hotko et al.
patent: 3608030 (1971-09-01), Tint
patent: 5008113 (1991-04-01), Kokubo et al.
patent: 5162117 (1992-11-01), Stupak et al.
patent: 5217720 (1993-06-01), Sekigawa et al.
Journal of Controlled Release, 2 (1985), pp. 27-38.
Chem. Pharm. Bull., 40(11), pp. 3036-3041 (1992).
Annals New York Academy of Sciences, vol. 618, pp. 428-440 (1991).
Science, vol. 233, pp. 1081-1084 (1986).

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