Pharmaceutical preparation containing protein C and a thrombolyt

Details Pharmaceutical preparation containing protein C and a thrombolyt Pharmaceutical preparation containing protein C and a thrombolyt

1995-06-01

1998-11-03

Marx, Irene

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 435212, 435214, 435215, 435216, 530380, 530381, 514822, 514834, A61K 3848, C12N 948, C12N 970, C12N 972

Patent

active

058304673

ABSTRACT:
A pharmaceutical preparation contains protein C and a thrombolytically active substance that does not activate protein C. This preparation prevents reocclusion usually occurring in the course of thrombolysis therapy.

REFERENCES:
patent: 5084274 (1992-01-01), Griffin et al.
Kohler et al., "Coninuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity," Nature, vol. 256, pp. 495-497 (Aug. 1975).
Stassen et al., "Thrombolysis with Human Extrinsic (Tissue-Type) Plasminogen Activator in Rabbits with Experimental Jugular Vein Thrombosis," J. Clin, Invest., vol. 71, pp. 368-376 (Feb. 1983).
Gruber et al., "Inhibition of Thrombus Formation by Infusion of Activated Protein C with Urokinase in a Primate Thrombosis Model," Blood, vol. 74, No. 7, Suppl. 1, Abstract No. 176 (Nov. 1989).
Yang et al., "Plasminogen, Alpha.sub.2 -antiplasmin, and Protein C Decline Following Infusions of Recombinanat Tissue Plaminogen Activator," Seminars in Thrombosis and Hemostasis, vol. 16, No. 3, pp. 242-244 (1990).
Gulba et al., "Increased Thrombin Levels During Thrombolytic Therapy in Acute Myocardial Infarction," Circulation, vol. 83, No. 3, pp. 937-944 (Mar. 1991).
Eisenberg et al., "Differential Effects of Activation of Prothrombin by Streptokinase compared With Urokinase and Tissue-Type Plasminogen Activator", Thrombosis Research, vol. 50:707-717, (1988).
Okajima et al., "Effect of Protein C and Activated Protein C on Coagulation and Fibrinolysis in Normal Human Subjects", Thrombosis and Haemostasis, vol. 63:48-53, (1990).
Vukovich et al., Replacement Therapy for a Homozygous Protein C Deficiency-State using a Concentrate of Human Protein C and S, British Journal of Haematology, vol. 70, 435-440, 1988.
Sigma Catalog, Sigma Chemical Company, p. 853, 1990.
Seligsohn et al., Homozygous Protein C Deficiency Manifested By Venous Thrombosis in the Newborn. N Engl. J. Med, 310:559-562, 1984.
Juhan-Vague et al., Plasma Levels of a Specific Inhibitor of Tissue-Type Plasminogen Activator (and Urokinase) in Normal and Pathological Conditions. Thromb. Res. 33:523-530, 1984.

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