Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Gas produced in situ by chemical reaction
Patent
1985-11-04
1988-08-09
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Gas produced in situ by chemical reaction
424489, 424500, 424501, 514570, A61K 946
Patent
active
047627026
ABSTRACT:
A pharmaceutical preparation containing ibuprofen is disclosed. In the preparation, the ibuprofen particles are enveloped by a coating of a hydro-colloid and fumaric acid. Preferably, the hydro-colloid comprises xanthan gum and/or maltodextrin. This preparation reduces the tendency of ibuprofen to irritate the esophagus and the gastrointestinal tract when taken orally. An effervescent mixture of the ibuprofen containing preparation can be prepared by incorporating citric acid and calcium carbonate into the mixture. A process for the manufacture of the ibuprofen containing preparation is also disclosed. In this process, ibuprofen particles are coated with the hydro-colloid and fumaric acid under vacuum conditions in a vacuum mixing machine and the resulting preparation is thereafter vacuum-dried.
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Gergely Gerhard
Gergely Irmgard
Gergely Thomas
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