Pharmaceutical preparation containing cyclosporine(s) for intrav

Details Pharmaceutical preparation containing cyclosporine(s) for intrav Pharmaceutical preparation containing cyclosporine(s) for intrav

1993-05-12

1996-06-18

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

436829, 264 41, A61K 9127, B01J 1302

Patent

active

055275370

ABSTRACT:
A pharmaceutical preparation is disclosed which contains one or several cyclosporine(s), one or several natural oils, 3-sn-phosphatidyl choline and/or phosphatidyl ethanol amine and water.

REFERENCES:
patent: 4388307 (1983-06-01), Cavanak
patent: 5206219 (1993-04-01), Desai
patent: 5294604 (1994-03-01), Nussemblatt et al.
WPI/print out No. 86-335072. Mizushima. 1 page.
WPI/print out No. 92-352740. Green Cross Corp. 1 page.
A. Tibell, et al. Cyclosporine A in Fat Emulsion Carrier: Immunosuppressive Effect in Vitro. Scand. J. Immunol. 35. pp. 231-236. 1992.
A. Yanagawa, et al. Selective transfer of cyclosporin to thoracic lymphatic systems by the application of lipid microspheres. J. Microencapsulation, 1989, vol. 6, No. 2. pp. 161-164.
W. Homan, et al. Studies On The Immunosuppressive Properties of Cyclosporin A In Rats Receiving Renal Allografts. Transplantation. vol. 29, No. 5. pp. 361-366.
Y. Mizushima. Lipid Microspheres As Novel Drug Carriers. Drugs Exptl. Clin. Res XI(9). 1985. pp. 595-600.
A. Shah, et al. Effect of Co-Administration of Intralipid.TM. On the Pharmacokinetics of Cyclosporine In the Rabbit. Biopharmaceutics & Drug Disposition. vol. 12. 1991. pp. 457-466.
Abstract No. 86-335071/51, Teikoku Hormone Mfg. Ltd., Japan, Apr. 26, 1985.
J. Pharm Sci, Bd 79, Nr 3, 1919, S Venkataram, "Pharmacokinetics of two alternative dosage forms of cyclosporine: Liposomes and Intralipid".

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