Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-01-30
1997-02-04
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514951, 546321, A61K 3144
Patent
active
055998240
ABSTRACT:
The invention relates to pharmaceutical preparations, containing a specific crystal modification (subsequently called "modification II") of isopropyl-(2-methoxyethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (nimodipine) and to a process for its preparation.
REFERENCES:
patent: 3932645 (1976-01-01), Meyer et al.
patent: 4406906 (1983-09-01), Meyer et al.
Journal of Computed-Aided Molecular Design, vol. 4, No. 3, 1990; pp. 215-230; D. A. Langs et al. `Receptor Model for the Molecular Basis of Tissue Selectivity of 1, 4-Dihydropyridine Calcium Channel Drugs`.
Wang, et al., Acta Cryst, vol. C45, 1989, pp. 1748-1751 `Structure of the Calcium Channel Antagonist, Nimodipine`.
The Merck Index (1989), Merck & Co., Inc., Rahway, N.J., USA, p. 1036.
W. Bahr et al., Organische Stereochemie, 1973, Springer Publishers, pp. 93 and 94 (English translation).
Wang et al., "Structure of Calcium Antagonist, Nimodipine", Acta Crystallographica, Nov. 1989, vol. C45, Part 11, pp. 1748-1751.
Franckowiak Gerhard
Grunenberg Alfons
Hegasy Ahmed
Kanikanti Rango-Rao
M uck Wolfgang
Bayer Aktiengesellschaft
Cintins Marianne M.
Moezie M.
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