Pharmaceutical preparation comprising fat emulsion of fat microp

Details Pharmaceutical preparation comprising fat emulsion of fat microp Pharmaceutical preparation comprising fat emulsion of fat microp

1995-06-07

1997-07-22

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424499, 424502, 514937, 514938, 514558, 514561, 514 25, A61K 914, A61K 916, A61K 910

Patent

active

056501722

ABSTRACT:
A preparation comprising a fat emulsion of fat microparticles wherein said emulsion contains a stabilizer consisting essentially of a fatty acid, a basic amino acid and a saccharide is provided. In the preparation comprising a fat emulsion of fat microparticles of the present invention, said microparticles having a mean particle diameter of at most 100 nm are stable, and so the microparticles remain in blood without being uptaken by liver. Therefore in case of administering a pharmaceutical preparation prepared by using the above-mentioned preparation of the present invention, the pharmacological activity may be expressed at a desired site. Thus the preparation is extremely useful as a drug carrier for drug delivery system. Furthermore, the pharmaceutical preparation of the present invention which is lyophilized can be easily and rapidly reconstituted into the pharmaceutical preparation comprising a fat emulsion of stable fat microparticles having a mean particle diameter of about at most 100 nm by adding distilled water, even after a long-term storage.

REFERENCES:
patent: 4647586 (1987-03-01), Mizushime
patent: 4776971 (1988-10-01), Nakamura
patent: 4816247 (1989-03-01), Desai
patent: 5004756 (1991-04-01), Ogawa
patent: 5098606 (1992-03-01), Nakajima
patent: 5229422 (1993-07-01), Takahashi et al.
patent: 5278149 (1994-01-01), Provost

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