Pharmaceutical preparation comprising fat emulsion of fat microp

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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Other Related Categories

424499, 424502, 514937, 514938, 514558, 514561, 514 25, A61K 914, A61K 916, A61K 910

Type

Patent

Status

active

Patent number

056501722

Description

ABSTRACT:
A preparation comprising a fat emulsion of fat microparticles wherein said emulsion contains a stabilizer consisting essentially of a fatty acid, a basic amino acid and a saccharide is provided. In the preparation comprising a fat emulsion of fat microparticles of the present invention, said microparticles having a mean particle diameter of at most 100 nm are stable, and so the microparticles remain in blood without being uptaken by liver. Therefore in case of administering a pharmaceutical preparation prepared by using the above-mentioned preparation of the present invention, the pharmacological activity may be expressed at a desired site. Thus the preparation is extremely useful as a drug carrier for drug delivery system. Furthermore, the pharmaceutical preparation of the present invention which is lyophilized can be easily and rapidly reconstituted into the pharmaceutical preparation comprising a fat emulsion of stable fat microparticles having a mean particle diameter of about at most 100 nm by adding distilled water, even after a long-term storage.

REFERENCES:
patent: 4647586 (1987-03-01), Mizushime
patent: 4776971 (1988-10-01), Nakamura
patent: 4816247 (1989-03-01), Desai
patent: 5004756 (1991-04-01), Ogawa
patent: 5098606 (1992-03-01), Nakajima
patent: 5229422 (1993-07-01), Takahashi et al.
patent: 5278149 (1994-01-01), Provost

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