Pharmaceutical preparation based on Lys-plasminogen

Details Pharmaceutical preparation based on Lys-plasminogen Pharmaceutical preparation based on Lys-plasminogen

1991-10-08

1994-04-19

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

514 8, 514 12, 514822, 514922, 530380, 530829, 530381, 530831, 435217, 424 9464, A61K 914, A61K 3747, A61K 3702, A61K 3764

Patent

active

053043839

ABSTRACT:
There is disclosed a pharmaceutical preparation based on Lys-plasminogen and available in the lyophilized form. This preparation contains a serine-protease inhibitor and optionally an inhibitor co-factor, preferably in an amount of 0.5 to 30 nmol per mg Lys-plasminogen. This preparation is free of side-effects and may be used for the treatment and prophylaxis of plasminogen deficiency syndromes and thromboses as well as for the production of thromboresistant artificial organs.

REFERENCES:
Whitefleet-Smith, I. et al. "Expression of Human Plasminogen cDNA . . . " Arch. Biochem. Biophys. 271:390-399 (Jun. 1989).
Verstraete et al., "Randomized Trial of Intravenous Recombinant Tissue-Type Plasminogen Activator Versus Intravenous Streptokinase in Acute Myocardial Infarction", The Lancet pp. 842-847 (Apr. 13, 1985).
Lew et al., "The Hypotensive Effect of Intravenous Streptokinase in Patients With Acute Myocardial Infarction", Circulation, 72:1321-1326 (1985).
Vitoux et al., "Treatment of Acute Peripheral Arterial and Graft Thromboses With Intra-Arterial Infusion of Urokinase and Lys-Plasminogen", Trubestein ed., in Konservative Therapie arterieller Durchblutungsstorungen, International Symposium on Conservative Therapy of Arterial Occlusive Diseases, Verlag, Stuttgart pp. 430-432.
Naito, "Study on Thrombolytic Therapy With Lysyl Plasminogen in Patients with Cerebral Thrombosis", Trubestein ed, in Konservative Therapie arterieller Durchblutungsstorungen, International Symposium on Conservative Therapy of Arterial Occlusive Diseases, Verlag, Stuttgart, pp. 343-351.
Rickli and Cuendet, "Isolation of Plasmin-Free Plasminogen with N-terminal Glutamic Acid", Biochem. Biophys. Acta., 250:447-451 (1971).
Markwardt et al., "Fibrinolytika und Antifibrinolytika", VEB Gustav Fischer Verlag, Jena, pp. 95-101, (1972).
Harpel, "Plasma Protease Inhibitors", Proc. Int. Workshop on Protein Separation and Plasma Fractionation, Ed. H. E. Sandberg, pp. 289-302 (1977).

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