Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-06-20
1980-02-26
Wheeler, David
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
546155, A61K 3147
Patent
active
041906594
ABSTRACT:
Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acid esters, e.g., 1-methyl-4-hydroxy-2-quinolinone-3-carboxylic acid ethyl ester, useful as anti-allergic agents and intermediates for 1-alkyl-4-alkoxy-quinolin-2(1H)-ones, and prepared by reacting an isatoic anhydride with an alkali metal salt of a malonic ester.
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patent: 3772305 (1973-11-01), Hellerbach et al.
patent: 4107310 (1978-08-01), Allais etal.
patent: 4119720 (1978-10-01), Hardtmann
McCorkindale, Tetrahedron, 1961, vol. 14, pp. 223-229.
Coutts et al., Chem. Abst., 1962, vol. 57, p. 5891(e).
Brown, Ibid, 1955, vol. 50, p. 1010(c).
Burger, Medicinal Chemistry, 1963, p. 42 (Interscience Pub. Co.).
Asahina et al., Berich. Deutchen Chem. Gessellschaft, vol. 63, 1930, pp.2052ff.
Grundon et al., Source not available, (1955), pp. 4284-4290.
Brown, "Australian J. Chem.", (1954), vol. 8, pp. 348-377.
Sandoz Inc.
Sharkin Gerald D.
Vila Richard E.
Wheeler David
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