Pharmaceutical multicomponent systems and method of preparing sa

Details Pharmaceutical multicomponent systems and method of preparing sa Pharmaceutical multicomponent systems and method of preparing sa

1985-02-22

1988-01-12

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Carboxylic acid ester

514938, 514941, 514942, 514943, 514962, 514966, 514967, A61K 4700

Patent

active

047192399

ABSTRACT:
The invention relates to liquid, transparent, multicomponent systems for use in pharmaceutical products for cutaneous, peroral, vaginal and parenteral administration of pharmaceutical active agents. The multicomponent systems according to the invention contain the active agents in a solution of an oily and optionally an aqueous component in the presence of certain physiologically acceptable surfactants and cosurfactants. Under certain conditions, the cosurfactants can serve as oil components or the latter can optionally take over the cosurfactant function. The biological availability of the active agents applied in the form of the multicomponent systems according to the invention is much better than that of active agents applied in the form of known multicomponent systems.

REFERENCES:
patent: 4073943 (1978-02-01), Wretlind et al.
patent: 4146499 (1979-03-01), Rosano
patent: 4184978 (1980-01-01), France et al.
patent: 4422952 (1983-12-01), Koulbonis et al.
patent: 4567161 (1986-01-01), Posanski et al.
Chem. Abstract 98: 40582w 1983.
Rimlinger, G., Chemical Abstracts, vol. 92, (1980), p. 333, No. 186335r.

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