Pharmaceutical methods and compositions

Details Pharmaceutical methods and compositions Pharmaceutical methods and compositions

1981-01-19

1982-07-13

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

A61K 3700

Patent

active

043394396

ABSTRACT:
Enhanced antiulcer activity is obtained in warm-blooded animals by the concomitant administration of the histamine H.sub.2 -receptor antagonist, etintidine, and the pepsin complexing agent, pepstatin. Concomitant administration of the two entities reduces the amount of etintidine necessary for effective treatment, thereby decreasing its side effect liability.

REFERENCES:
patent: 4101650 (1978-07-01), Umezawa
patent: 4112234 (1978-09-01), Crenshaw et al.
Myers et al., Clinical Research, 28, 30A 1980.
Umezawa et al., J. Antibiotics 23, 259-262, 1970.
Bonnevie et al., Gut, 20, 624-628 (1979).
Svendsen et al., Scand. J. Gastroent. 14, 929-932 (1979).
Strauss et al., Surg. Forum 28, 361-363, 1977.
Dajani et al., J. Pharmacol. Exp. Ther., 210, 373-377, (1979).
British Medical Journal 95-96, (1980).

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