Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1996-05-03
1999-01-05
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514212, 514921, A61K 31175, A61K 3155
Patent
active
058563601
ABSTRACT:
This invention is directed to a pharmacologically acceptable composition for inhibiting or treating hemorrhagic shock in a mammal. The composition includes a K.sub.ATP inhibitor and a pharmacologically acceptable carrier, with the K.sub.ATP inhibitor being present in an amount sufficient to inhibit or treat hemorrhagic shock in the mammal. The invention is also directed to a method for inhibiting or treating hemorrhagic shock in a mammal. The method includes administering to the mammal an amount of a K.sub.ATP channel inhibitor sufficient to inhibit or treat hemorrhagic shock in the mammal. In a preferred form of the invention, the K.sub.ATP channel inhibitor is selected from the group consisting of a sulfonylurea, a guanidine, a phenothiazine, an imidazoline, TMB-8 (also known as (8-N, N-diethylamino) octyl-3,4,5-trimethoxybenzoate), 2,3-butanedione monoxime, disopyramide, gliquidone, chlorpromazine, AMP-NPP (also known as 5'-adenylylamidodiphosphate), flecainide, MS-551 (also known as propylamino!ethylamino)-2,4(1H,3H)-pyrimidinedione HCl) and combinations thereof.
REFERENCES:
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"The ATP-Sensitive K.sup.+ Channel Mediates Hypotension in Endotoxemia and Hypoxic Lactic Acidosis in Dog", by: Donald W. Landry and Juan A. Oliver, (J. Clin. Invest., vol. 89, Jun., 1992), pp. 2071-2074.
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Science, vol. 270, No. 5239, 17 Nov. 1995, pp. 1166-1170, Inagaki, N. et al., "Reconstitution of /Katp: An Inward Rectifier Subunit Plus The Sulfonylurea Receptor".
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Eur J Pharmacol, May 30, 1991, 198 (1) P101-4, Netherlands, Muller, M. et al.: "Chlorpromazine and related phenothiazines inhibit the ATP--sensitive K+channel".
Salzman Andrew L.
Szabo Csaba
Children's Hospital Medical Center
Cintins Marianne M.
Moezie M.
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