Pharmaceutical hydrophilic spray containing nitroglycerin for tr

Details Pharmaceutical hydrophilic spray containing nitroglycerin for tr Pharmaceutical hydrophilic spray containing nitroglycerin for tr

1992-12-11

1994-12-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

12820013, 12820014, 141 20, 215247, 222394, 424 45, A61K 912

Patent

active

053708628

ABSTRACT:
A pharmaceutical aerosol spray for treating an angina attack including a container having a liquid composition therein comprising 0.1 to 2 weight percent of nitroglycerin, 2 to 60 weight percent of ethanol, 2 to 60 weight percent of propylene glycol, 10 to 50 weight percent of dichlorodifluoromethane and 30 to 70 weight percent of dichlorotetrafluoroethane, the container having a valve assembly sealed to the container around an opening in the container by a sealant material which has a nitroglycerin absorption value less than 10 mg/1 g of sealant material.

REFERENCES:
patent: 3155574 (1964-11-01), Silson et al.
patent: 4349135 (1982-09-01), Busselet
patent: 4440777 (1984-04-01), Zupan
patent: 4487334 (1984-12-01), Werding
patent: 4621964 (1986-11-01), Radtke et al.
patent: 4744495 (1988-05-01), Warby
patent: 4752466 (1988-06-01), Saferstein et al.
patent: 4895719 (1990-01-01), Radhakrishnan et al.
patent: 5047230 (1991-09-01), Nagy et al.
patent: 5125466 (1992-06-01), Felt et al.
Merck Index, 10th ed., Windholz et al. (1983) p. 1095, 7456 Poltyef.

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