Pharmaceutical granulate

Details Pharmaceutical granulate Pharmaceutical granulate

1989-02-24

1992-02-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424494, 424686, 424692, 514819, A61K 916, A61K 3306

Patent

active

050858696

ABSTRACT:
A wet granulate is provided for therapeutically useful substances having a water solubility 10 wt % or less and microcrystalline or microfine cellulose or a mixture of both, where substantial amounts of wet binders are avoided.
Tableting mixtures with the new granulate possess a good flow pattern and may be compressed to tablets which show an excellent disintegration behavior.

REFERENCES:
patent: 4292299 (1981-09-01), Suzuki et al.
patent: 4454108 (1984-06-01), Iida et al.
patent: 4665081 (1987-05-01), Doi et al.
patent: 4753801 (1988-06-01), Oren et al.
patent: 4777033 (1988-10-01), Ikura, et al.
patent: 4837030 (1989-06-01), Valorose, Jr. et al.
The Merck Index, 10th Ed., (1983), p. 810, reference no. 5478, "Magnesium Carbonate Hydroxide".

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