Pharmaceutical gel preparation applicable to mucosal surfaces an

Details Pharmaceutical gel preparation applicable to mucosal surfaces an Pharmaceutical gel preparation applicable to mucosal surfaces an

1998-04-22

2000-08-15

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

514781, A61K 914, A61K 4700, A01N 2500

Patent

active

061032662

ABSTRACT:
The present invention relates to a non water-soluble pharmaceutical carrier gel which adheres to mucosal surfaces and body tissues upon application and forms a film, providing protection and delivery of pharmaceutical to the site of application, surrounding body tissues, and bodily fluids. The gel comprises a volatile or diffusing nonaqueous solvent and at least one non-water-soluble alkyl cellulose or hydroxyalkyl cellulose. A bioadhesive polymer may also be added. The gel provides an effective residence time with ease of use. The residence time may be adjusted by adding a component which acts to adjust the kinetics of erodability of the carrier.

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