Pharmaceutical formulations that have a biologically active hydr

Details Pharmaceutical formulations that have a biologically active hydr Pharmaceutical formulations that have a biologically active hydr

1994-02-16

1997-08-12

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424456, 424463, 424450, 514 2, 514 3, 514 21, 514866, 514937, 514938, 514941, 514943, A61K 9107, A61K 948, A61K 9127

Patent

active

056562896

ABSTRACT:
Orally or rectally administrable formulations of biologically active material comprise a water-in-oil microemulsion, wherein the hydrophilic phase of the microemulsion comprises the biologically active material and the hydrophobic phase comprises chylomicra or material capable of forming chylomicra in the intestinal mucosa after administration. The biologically active material may be any of a wide range of substances including insulin, calcitonin and somatotrophin or growth hormone. Formulations of the invention are particularly suitable for the oral administration of insulin in the treatment of diabetes.

REFERENCES:
patent: 4146499 (1979-03-01), Rosano
patent: 4165385 (1979-08-01), Lefebvre
patent: 4536324 (1985-08-01), Fujiwara et al.
patent: 4849227 (1989-07-01), Cho
patent: 4851220 (1989-07-01), Yim
patent: 4855090 (1989-08-01), Wallach

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